
What Is Rejuran PN? And How It Works
Rejuran, also known as Rejuran Healer, is a skin booster treatment developed in South Korea that repairs, rejuvenates, and restores skin from within. It contains polynucleotides (PN)—bio-molecules derived from salmon DNA that are highly biocompatible with human skin.
When injected into the dermis, these PN molecules stimulate cell regeneration, improve the skin’s microenvironment, and trigger collagen production. Over time, the skin becomes firmer, smoother, and more resilient.
Who Is Rejuran Suitable For?
Rejuran is ideal for individuals who want to:
- Repair damaged or ageing skin at a cellular level
- Improve acne scars and fine wrinkles
- Restore hydration and elasticity
- Reduce enlarged pores and uneven texture
- Prevent premature skin ageing
Rejuran is most commonly recommended for adults aged 25 and above, especially those noticing early signs of ageing or skin damage from sun exposure.

Key Benefits of Rejuran
- Skin Repair – Heals micro-damage and strengthens the skin barrier
- Anti-Ageing – Improves elasticity, reduces fine lines, and smooths roughness
- Scar Improvement – Effective in reducing the appearance of acne scars
- Hydration Boost – Enhances moisture retention for healthier skin texture
- Long-Term Results – Stimulates collagen and tissue regeneration for sustained improvements
Rejuran vs Other Skin Boosters
- Hyaluronic Acid Skin Boosters – They focus mainly on hydration and plumping the skin.
- Profhilo – It is a bioremodelling injectable that hydrates and stimulates collagen, but has a higher HA concentration.
- Rejuran – Goes beyond hydration by repairing and healing skin at the DNA level, making it especially effective for ageing and damaged skin.
Many patients combine Rejuran with other injectables (e.g. HA Skinboosters or Profhilo) for comprehensive skin rejuvenation.
What to Expect During & After Rejuran Treatment
- During Treatment: A numbing cream is applied for comfort. Rejuran is injected into the dermis using fine needles. Treatment time is about 30 minutes.
- After Treatment: Small visible bumps (injection marks) may appear, especially on thinner skin areas like under the eyes. These usually settle within 24–48 hours.
- Downtime: Minimal downtime is expected with most patients resume normal activities the next day.
Recommended Rejuran Session Frequency
- Initial Treatment: The initial treatment comprises 3–4 sessions, spaced 3–4 weeks apart.
- Maintenance: Every 6–12 months, your aesthetician will recommend maintenance sessions, depending on skin condition and lifestyle.
With time, results become more visible, with skin quality continuing to improve for months after the final session.
Rejuran Side Effects & Recovery Timeline
Rejuran is generally safe when administered by trained doctors. Possible side effects include:
- Temporary redness, swelling, or bruising at injection sites
- Small visible bumps (typically disappear within 1–2 days)
- Rare allergic reactions (though uncommon due to high biocompatibility)
Most patients experience only mild downtime and notice improved skin radiance within weeks.
Why Choose Aeon Medical for Rejuran?
At Aeon Medical, we focus on personalised, medically-backed treatments. Our doctors customise Rejuran protocols to your skin’s condition and goals, ensuring safe and effective results.
We use only authentic, approved Rejuran products and deliver them with precision techniques that maximise comfort and minimise downtime. Our priority is natural-looking results that restore your skin’s health, not just its appearance.
Book a Rejuran Consultation Today
Are you ready to repair and rejuvenate your skin from within? Schedule your Rejuran consultation at Aeon Medical and let our doctors tailor a treatment plan that works best for you.
Frequently Asked Questions (FAQs) About Rejuran (PN) Treatment in Singapore
Polynucleotide (PN) used in Rejuran is a type of biological molecule similar to DNA in cells and is extracted from salmon. The main reason salmon was used is because salmon DNA was found to have beneficial effects on human skin and the DNA is very similar to human DNA. Researchers found that salmon DNA is safe and it is purified to prevent side effects such as allergic reactions. PN can help the skin by providing anti-inflammatory and wound healing mechanisms which in turn can help to stimulate collagen and improve hydration and elasticity of the skin.
Disclaimer
The information provided on this website is for educational purposes only and is, in no way, intended to be a substitute for professional medical advice, diagnosis, or treatment. We make no representation or warranty of any kind regarding the accuracy, availability, adequacy, or validity of the information or procedures outlined on the website. Always consult professional medical and aesthetic advice for your skincare and medical concerns.
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