Profhilo Treatment in Singapore: The Complete 2025 Guide

In recent years, Singapore has seen a surge in demand for non-surgical aesthetic treatments that promise natural results with minimal downtime. Among them, Profhilo treatment is commonly used in Singapore clinics for skin rejuvenation.

Unlike traditional fillers or Botox, Profhilo isn’t about adding volume or freezing wrinkles. Instead, it works at a cellular level to boost hydration, stimulate collagen, and improve overall skin quality. Intended outcomes include firmer, smoother, and more radiant skin with natural-appearing changes.

If you are considering Profhilo treatment in Singapore, this guide will walk you through everything you need to know: what it is, how it works, its benefits, the procedure, safety, costs in Singapore, and how it compares with other treatments.

Quick Summary

Key Facts

• What Profhilo is: Injectable HA bio-remodeller
• Dose: 64 mg HA / 2 mL syringe
• Protocol: 2 sessions, 4 weeks apart
• Downtime: Small bumps 24–48 h; most activities same day
• Longevity: ~6–12 months (varies)

Pre-treatment checklist

• Avoid alcohol & strenuous exercise 24 h before.
• Tell your doctor if you are taking any blood thinners/NSAIDs; follow advice.
• Arrive with clean skin; pause strong actives (retinoids/AHAs) on the day.
• Reschedule if you have an active skin infection/cold sore.

Results timeline

• 0–24 h: Tiny bumps; mild redness/itching possible.
• Day 2–3: Bumps settle; early hydration glow.
• Week 4: Session 2.
• Weeks 6–8: Peak improvement in elasticity & texture.
• Months 6–9: Consider maintenance sessions.

What is Profhilo?

Profhilo is an injectable bio-remodelling treatment made from ultrapure hyaluronic acid (HA). It was developed in Italy by IBSA Derma and is now used in over 80 countries worldwide.

Unlike dermal fillers, which are cross-linked to provide structure and volume, Profhilo uses a stabilised hybrid of high and low molecular weight hyaluronic acid (HA). This unique formulation allows it to spread evenly under the skin, hydrating from within while stimulating the production of collagen and elastin.

In short, Profhilo is not a filler and not a skin booster. It is in its own category, designed to improve skin quality rather than alter facial features.

How Profhilo Works: The Science Behind It

Profhilo is often described as a “bio-remodelling treatment” because it does more than just hydrate. It actively stimulates the skin to regenerate from within. Its power lies in its dual-action formulation of hyaluronic acid (HA), which has been carefully designed to achieve both immediate and long-term results.

Hydration Boost (Immediate Effect)

When Profhilo is administered, one of the immediate effects is increased hydration. 

• Profhilo contains low molecular weight HA, which penetrates more easily into the skin’s deeper layers.
• This type of HA has a strong ability to attract and bind water molecules, instantly increasing skin hydration levels.
• The result is skin that looks plumper, smoother, and more radiant. Hence, patients describe a refreshing glow instantly.

Bio-Remodelling (Long-Term Effect)

Beyond the immediate effects of hydration, Profhilo continues to work long-term to provide other skin-tightening effects. The difference between fillers and Profhilo is that, unlike fillers, which provide instant volume, Profhilo works more subtly — gradually reprogramming the skin to renew itself.

• Alongside hydration, Profhilo also contains high molecular weight HA.
• This works by stimulating fibroblast activity in the skin. These cells are responsible for producing collagen and elastin, the key building blocks of youthful, firm skin.
• Over time, this process leads to a noticeable improvement in:
  • Skin elasticity (tighter, firmer skin).
  • Reduction of fine lines and crepey texture.
  • Improved overall skin tone and resilience.

Key Facts About Profhilo

Few of the key aspects of Profhilo include:

• High concentration of HA: Each Profhilo syringe contains 64mg of ultrapure HA per 2mL syringe, one of the highest concentrations available globally. This makes it more potent than traditional skin boosters.
• Innovative BAP technique: The treatment is injected at five specific points on each side of the face, the Bio Aesthetic Points (malar, nasolabial fold, chin, mandibular angle, preauricular). These points were chosen strategically to minimise risks and maximise even distribution of the product, allowing it to spread smoothly across the entire mid- and lower face.
• Treatment protocol: For optimal results, most patients undergo two sessions spaced 4 weeks apart. Improvements continue to build after the second session, with results lasting around 6–12 months, depending on individual factors.

Areas Commonly Treated With Profhilo

While Profhilo treatment is most often used for the face, its versatility makes it suitable for multiple areas prone to ageing and skin laxity. Because Profhilo spreads naturally under the skin, it works well in areas that need overall skin quality improvement rather than targeted contouring.

• Face – The face is the most highly treated area with Profhilo, especially the cheeks, jawline, and lower face, where skin often loses elasticity first.
• Neck – The neck is a delicate area where sagging and fine lines become noticeable early. Therefore, Profhilo is also used to treat skin sagging in the neck. 
• Décolletage (chest) – Profhilo is also used to treat crepey skin and sun damage at the chest area.
• Hands – One of the first areas in our bodies that show visible signs of ageing and volume loss are the hands. Profhilo also shows promising results in skin quality of the hands.

In essence, Profhilo is not just a superficial skin hydrator — it is a treatment that rebuilds the skin’s foundation over time, creating firmer, healthier, and more radiant skin that looks refreshed yet completely natural.

Benefits of Profhilo Treatment in Singapore

Profhilo is often praised for giving the skin a “glow from within” — but its benefits go well beyond hydration. Unlike traditional fillers or Botox, Profhilo works holistically, improving the overall quality, firmness, and health of the skin. Here’s what makes it one of the most in-demand treatments in Singapore today:

Deep Hydration for Radiant Skin

• With one of the highest concentrations of hyaluronic acid, Profhilo floods the skin with intense moisture.
• It’s especially effective for dull, dry, or tired-looking skin caused by Singapore’s humid climate, air-conditioned environments, or natural ageing.
• The hydration effect restores the skin’s dewy, plump appearance, making it look fresher and healthier.

Improved Elasticity and Firmness

• By stimulating collagen and elastin production, Profhilo strengthens the skin’s structure.
• This translates into firmer, tighter skin — especially around the jawline, cheeks, and neck, which are often the first areas to sag.
• Patients notice their skin feels more resilient and “bounces back” better.

Reduction in Fine Lines and Crepey Texture

• Profhilo does not add volume to the skin. It supports hydration and dermal remodeling, which may reduce the appearance of fine lines over 4–8 weeks.
• It’s particularly effective for:
  • Fine lines around the eyes and mouth.
  • Crepey skin on the neck and chest.
  • Early wrinkles caused by loss of elasticity.
• Results are subtle, but the skin looks softer and more youthful.

Brighter, More Even Skin Tone

• Beyond texture, Profhilo also improves skin radiance and tone.
• Many patients describe their complexion as brighter and more refreshed, with a visible glow that makeup can’t replicate.
• This makes it a popular choice before important events or social occasions.

Natural, Subtle Results

• Unlike dermal fillers, Profhilo doesn’t add bulk or alter facial contours.
• The results are natural-looking and subtle, enhancing your features without making you look “done.”
• Friends and colleagues may notice you look fresher and healthier, but not be able to tell you’ve had a treatment.

Minimal Downtime

• The procedure is quick (about 30 minutes) and recovery is minimal.
• Small bumps at the injection points usually settle within 24–48 hours.
• Most patients return to work or daily activities immediately with minimal downtime. That is why it is a favourable option for busy Singaporeans.

Versatility Across Multiple Areas

• Profhilo isn’t limited to the face. It can be used to rejuvenate the neck, décolletage, and hands, areas often neglected but quick to show ageing.
• This versatility makes it a comprehensive anti-ageing solution.

Preventive Anti-Ageing

• For younger patients in their 30s and 40s, Profhilo works as a preventive treatment, delaying the onset of sagging and wrinkles.
• By stimulating collagen early, Profhilo helps maintain youthful skin for longer.

Who is Profhilo Suitable For?

Profhilo is ideal for individuals looking to prevent or address early signs of ageing.

Ideal Candidates:

• Adults in their 30s–60s noticing loss of skin elasticity or hydration.
• Those with fine lines, mild sagging, or crepey skin.
• Individuals who want subtle, natural results without altering facial structure.
• Both men and women, although it is becoming increasingly popular among male patients.

Not Suitable For:

• Pregnant or breastfeeding women.
• People with active skin infections at the injection site.
• Those with a history of severe allergies to HA or injection ingredients.
• Relative cautions: autoimmune disease, anticoagulant use—discuss with your doctor

The Profhilo Procedure: What to Expect

One of the biggest reasons Profhilo has become so popular in Singapore is its simplicity and minimal downtime. Unlike surgery or even more invasive injectables, Profhilo is quick, straightforward, and designed to fit into a busy lifestyle. Here’s what you can expect before, during, and after your treatment.

Step-by-Step Process

1. Initial Consultation

Your journey begins with a comprehensive consultation with a qualified aesthetic doctor. During this session:

• The doctor will assess your skin condition (hydration levels, elasticity, fine lines, areas of laxity).
  
• Your treatment goals will be discussed — whether that’s improving overall skin quality, reducing fine lines, or targeting the neck or décolletage.
  
• The doctor will also review your medical history to confirm you are a suitable candidate and address any concerns.
• At this time, you can ask questions about expected results, how long they last, and whether Profhilo should be combined with other treatments for optimal results.

2. Preparation

• The treatment area is thoroughly cleansed and disinfected to reduce the risk of infection.
• While Profhilo injections are generally well-tolerated, a topical numbing cream may be applied, especially for patients concerned about discomfort.
• The skin is then marked with the Bio Aesthetic Points (BAP) — five precise injection sites on each side of the face. These points are carefully chosen to minimise risks while ensuring even distribution of the product.

3. Injection Process

• Using a fine needle, the doctor injects small amounts of Profhilo into the five BAP points per side of the face. These typically include:
  • Near the ear
  • Below the side of the nose
  • Along the chin
  • On the lower cheek
  • Near the jawline
• The technique ensures that Profhilo spreads naturally under the skin, delivering hydration and stimulation evenly.
• Patients usually describe the sensation as mild stinging or pressure, rather than pain.

4. Duration of Treatment

The entire procedure is surprisingly quick. From preparation to final injection, most sessions take about 30 minutes. Many patients choose to schedule it during a lunch break. The session typically takes ~30 minutes and involves minimal downtime.

5. Post-Treatment Experience

• After the injections, you may notice small bumps at the injection sites. These are tiny deposits of hyaluronic acid and are a normal part of the process.
• The bumps usually settle within 12–24 hours, as the product spreads through the skin.
• Some patients may experience mild swelling, redness, or bruising, but these side effects are temporary and resolve quickly.

Downtime and Recovery of Profhilo

One of Profhilo’s biggest advantages is its minimal downtime. Most people resume work or daily activities on the same day. To maximise results and minimise risks, doctors typically recommend:

• Avoiding strenuous exercise, alcohol, saunas, and hot yoga for 24–48 hours.
• Steering clear of facials, massages, or other skin treatments for a few days.
• Applying sunscreen daily to protect newly treated skin.

Within a few days, your skin will already feel more hydrated and plump, but the full effects of Profhilo become more noticeable after the second session, as collagen and elastin production kicks in.

Safety, Side Effects, and Aftercare of Profhilo

Profhilo is generally considered safe and well-tolerated when administered by a qualified doctor.

Common Side Effects (temporary):

There could be some common side effects, but those, too, are temporary. They may include:

• Redness
• Tenderness/itching
• Swelling at injection points
• Small lumps or bumps (subside within 1–2 days)
• Mild bruising

Rare Risks:

Certain serious side effects, although quite rare, may include:

• Infection at the injection site (prevented by sterile technique).
• Allergic reaction (extremely rare due to Profhilo’s ultrapure HA formulation).
• Vascular events

Aftercare Tips:

Follow these aftercare tips to emsure a smooth recovery and maximum results. 

• Avoid touching or massaging treated areas.
• Skip facials, saunas, and vigorous workouts for 1–2 days.
• Keep skin hydrated and use sunscreen.

Profhilo vs Other Skin Treatments in Singapore

Profhilo often gets compared with other injectables for improving skin’s feel and appearance. Here is a comparison to see how it differs from other popular aesthetic treatments in Singapore:

Treatment	What it Does	Best For
Profhilo	Boosts hydration, stimulates collagen & elastin	Overall skin quality, firmness, glow
Dermal Fillers	Add volume, contour	Cheeks, lips, chin, under-eye hollows
Skin Boosters	Hydrate skin with HA	Superficial hydration, smoother skin
Botox	Relaxes muscles	Wrinkle reduction (forehead, crow’s feet)
Rejuran Healer	Polynucleotide-based repair	Healing, acne scars, skin texture improvement

Profhilo is unique because it improves skin health and elasticity rather than focusing on volume or muscle movement.

Cost of Profhilo Treatment in Singapore (2025 Update)

The cost of Profhilo in Singapore varies depending on the clinic and the doctor’s expertise.

• Average cost per session: SGD $800 – $1,200
• Recommended protocol: 2 sessions, 4 weeks apart
• Maintenance: 1 session every 6–9 months

Factors Influencing Cost of Profhilo in Singapore:

• Clinic reputation and location
• Doctor’s qualifications and experience
• Number of treatment areas (face, neck, hands, etc.)
• Whether additional treatments are combined

Important Tip: Be cautious of clinics offering very low prices — authentic Profhilo is only supplied through authorised distributors, and counterfeit injectables are a risk in the market.

Choosing the Right Clinic for Profhilo in Singapore

The success of Profhilo depends on the skill of the person carrying out the procedure and injecting your skin.  Remember that Profhilo is safe when administered correctly, but improper injection techniques can cause uneven results or complications. Here’s what you should look for while selecting an aesthetic clinic in Singapore:

• MOH-licensed aesthetic clinic
• Doctor-led treatments (not therapists or beauticians)
• Experience with injectables and facial anatomy
• Transparent pricing with clear breakdowns
• Before-and-after photos or case studies

Why Aeon Medical for Profhilo?

At Aeon Medical and Aesthetic Clinic, we believe in treatments that enhance your natural beauty while prioritising safety and patient comfort.

• MOH-licensed aesthetic clinic; doctor-administered injections
• Authentic Profhilo obtained via authorised distributors
• Individualised plans following medical consultation and skin assessment
• Written aftercare and follow-up guidance provided

Whether you’re considering Profhilo for the first time or looking to maintain long-term skin health, Aeon Medical provides a professional, supportive environment to help you achieve your goals.

Final Thoughts: Is Profhilo Worth It?

Profhilo is an effective injectable for skin rejuvenation and skin quality improvement. With its ability to hydrate, firm, and improve overall skin quality, it offers results that are both subtle and natural.

For individuals in Singapore seeking a non-surgical, low-downtime treatment that enhances skin from within, Profhilo is a safe and effective choice.

At Aeon Medical, we take pride in delivering Profhilo treatments with effective standards of safety and patient care. If you’re ready to restore your skin’s vitality, book a consultation with our doctors and discover what Profhilo can do for you.

Frequently Asked Questions

Is Profhilo painful?

No, Profhilo is not particularly painful. Rather, most patients describe mild discomfort, but numbing cream can be applied to cater to it.

How long do the results of Profhilo last?

The results of Profhilo typically last for 6–12 months, depending on age, skin quality, and lifestyle.

How many sessions of Profhilo do I need?

Usually, you need 2 sessions of Profhilo, 4 weeks apart. After that, maintenance sessions are recommended every 6–9 months.

Can Profhilo be combined with other treatments?

Yes, Profhilo is commonly combined with fillers, Botox, or laser treatments for a comprehensive anti-ageing plan.

When will I see results from Profhilo?

Some improvement from Profhilo is visible within weeks, but optimal results appear after the second session.

Is Profhilo safe for sensitive skin?

Yes, Profhilo is highly biocompatible and safe, though suitability should be confirmed by your doctor.

When can I return to normal activities after having a Profhilo treatment?

Most people resume work immediately after a Profhilo session. However, you should avoid exercise, alcohol, or hot environments for 24–48 hours.

Disclaimer: 

The information in this article is for educational purposes and not a substitute for personalised medical advice. Always consult a qualified doctor regarding your specific condition and treatment options.