Your Guide to Rejuran in Singapore 2025 – What Is Rejuran, Costs and Science Behind It
In the world of aesthetic medicine, Rejuran has quickly become one of the most sought-after skin rejuvenation treatments in Singapore. This innovative therapy uses polynucleotides (PN), which are naturally occurring molecules that stimulate skin healing and regeneration. Polynucleotides are known for their ability to repair, restore, and revitalise the skin. But how does that happen? How does it transform the skin from within? This blog explores how polynucleotides work, the clinical evidence behind them, and what patients can expect when undergoing this treatment.
What Is Rejuran?
Rejuran is a skin booster treatment that uses polynucleotides (PN) derived from salmon DNA. These biocompatible molecules are purified to ensure they are safe for human use and are injected into the skin to stimulate natural healing.
The treatment was first developed in South Korea and has since become a trusted choice across Asia, particularly in Singapore, where demand for non-surgical anti-ageing solutions is high.
There are several types of Rejuran designed for different skin concerns:
- Rejuran Healer – appropriate for overall skin rejuvenation and repair.
- Rejuran S – targeted treatment for acne scars.
- Rejuran HB – focuses on hydration and barrier repair.
- Rejuran I – designed for delicate areas like under the eyes.
Understanding Polynucleotides (PN)
What are polynucleotides? Nucleotides are the building blocks of DNA, and polynucleotides are long chains of nucleotides. In aesthetic medicine, they are sourced from salmon DNA because of its strong biocompatibility with human skin.
To make them safe for cosmetic use by humans, they go through a purification process that prepares molecules free of proteins that could cause allergic reactions. These PN molecules are then injected into the skin. Once injected, PN acts at the cellular level to:
- Promote cell repair and regeneration.
- Stimulate fibroblasts, the skin cells that produce collagen and elastin.
- Improve microcirculation and skin barrier function.
How Rejuran Works: The Science Explained
The power of Rejuran lies in its ability to trigger the body’s natural healing processes at the cellular level. Unlike topical creams that only work on the skin surface, Rejuran delivers polynucleotides (PN) directly into the dermis through microinjections.
Once injected in the skin, PN molecules perform multiple roles:
- Cell Repair and DNA Protection
Polynucleotides act as building blocks for DNA repair. When skin cells are damaged by UV radiation, stress, or ageing, PN provide the raw materials that enable these cells to regenerate more efficiently. This process slows down skin ageing and strengthens the skin’s natural defence system. - Fibroblast Activation and Collagen Stimulation
Fibroblasts are specialised cells in the dermis that produce collagen and elastin. As we age, fibroblast activity declines, leading to sagging, wrinkles, and thinning skin. Rejuran’s PN stimulates fibroblasts back into action, encouraging new collagen synthesis and restoring elasticity. - Improved Blood Flow and Microcirculation
Research has shown that PN can enhance microcirculation to ensure that skin cells receive more oxygen and nutrients. When there is better blood flow, the process of healing starts, reducing inflammation and resulting in a healthier, more radiant complexion. - Anti-Inflammatory Properties
Polynucleotides naturally reduce oxidative stress and inflammation in the skin. This calming effect makes Rejuran particularly beneficial for individuals with sensitive or inflamed skin conditions, such as rosacea or post-acne redness. - Gradual and Long-Term Tissue Regeneration
Unlike fillers or treatments that give instant results, Rejuran works slowly and progressively. Over several weeks, patients notice gradual improvements in skin thickness, texture, and tone as the dermal tissue rebuilds itself from within.
In short, Rejuran does not simply “mask” ageing—it repairs the underlying skin structure, restoring vitality and resilience at a biological level.
Key Benefits of Rejuran
Rejuran is considered one of the most comprehensive skin-healing treatments available in Singapore because it addresses both cosmetic concerns and underlying skin health. Here are its most significant benefits:
Enhanced Skin Texture and Firmness
Rejuran helps promote collagen and elastin production. With increased collagen and elastin, the skin becomes firmer, smoother, and more supple. Fine lines soften, and sagging areas gain renewed elasticity.
Reduction of Fine Lines and Wrinkles
Rejuran works by repairing the dermis and boosting collagen synthesis. This helps minimise wrinkles gradually, especially in delicate areas like the under-eyes, where traditional treatments may be less suitable.
Stronger Skin Barrier and Deep Hydration
Rejuran improves the skin’s natural barrier function, which means better moisture retention and protection against environmental damage. This is especially useful in Singapore’s humid and hot environment. Patients often report that their skin feels more hydrated, plump, and less reactive to external stressors after taking Rejuran sessions.
Healing of Acne Scars and Damaged Skin
For patients struggling with post-acne scarring or uneven skin texture, Rejuran helps regenerate damaged tissue. Over multiple sessions, scars appear less pronounced, and overall skin texture becomes more even.
Calming and Anti-Inflammatory Effects
Thanks to its ability to reduce oxidative stress, Rejuran is well-suited for sensitive or inflamed skin. It can calm redness and irritation, and improve the overall skin tone.
Natural and Long-Lasting Results
Unlike treatments that offer instant but short-lived improvements, Rejuran works with the body’s own healing processes. Results may take a few weeks to become noticeable, but continue to improve over time, often lasting several months with proper maintenance.
Preventive Anti-Ageing Benefits
Rejuran is not only a corrective treatment option but also preventive. Younger patients in their late 20s and 30s can use it to strengthen skin health early on, delaying visible signs of ageing.
Scientific Evidence & Clinical Studies
Multiple clinical studies have shown that PN injections significantly increase collagen production, improve dermal thickness, and reduce visible signs of ageing. Research also highlights PN’s ability to repair UV-damaged skin, which is especially relevant in Singapore’s hot and humid climate.
In trials, patients demonstrated:
- Noticeable wrinkle reduction after 4–6 weeks.
- Improved skin elasticity and hydration.
- Long-term benefits last for several months post-treatment.
How often should I have Rejuran treatment?
Rejuran treatment usually spans 3–4 initial sessions spaced one month apart, followed by maintenance every 6–12 months.
Who Is Rejuran Suitable For?
Rejuran is recommended for adults in their late 20s and above, particularly those experiencing:
- Early signs of ageing (fine lines, dullness, mild sagging).
- Acne scars or uneven skin texture.
- Dehydrated or sensitive skin.
- Preventive anti-ageing goals.
Rejuran has a gentle formulation which makes it safe for patients with sensitive or reactive skin.
Possible Side Effects and Safety
Although Rejuran is considered very safe due to the biocompatibility of salmon-derived PN, you may notice a few temporary side effects. These may include:
- Mild redness or swelling.
- Tiny bumps at injection sites (which typically subside in 24–48 hours).
When performed by a certified medical professional, complications are rare.
Rejuran vs Other Skin Boosters
Rejuran is often compared with hyaluronic acid (HA) injectables. While hyaluronic acid (HA) injectables primarily hydrate and plump the skin, Rejuran focuses on repairing and regenerating skin tissue at the cellular level.
When compared to PRP (Platelet-Rich Plasma) treatments, Rejuran offers more predictable outcomes and avoids variability since it uses purified PN rather than relying on a patient’s own blood.
Cost of Rejuran in Singapore
On average, Rejuran treatments in Singapore range from $500 to $1,200 per session, depending on:
- The Rejuran variant used (Healer, S, HB, I).
- The doctor’s expertise and clinic reputation.
- Package options for multiple sessions.
Patients should always prioritise safety and expertise over price when choosing where to undergo treatment.
Rejuran Treatment Process at AEON Medical and Aesthetic Clinic
At AEON Medical, every Rejuran treatment is guided by a personalised approach that includes the following steps:
- Consultation & Assessment – Dr Jeslin Wong assesses skin concerns and recommends the appropriate Rejuran variant.
- Numbing & Preparation – A topical anaesthetic cream ensures comfort during the procedure.
- Microinjections – Rejuran is injected into targeted skin layers using fine needles.
- Downtime – Patients may notice small bumps or redness, typically subsiding within 1–2 days.
- Aftercare – Gentle skincare and sun protection are advised for optimal results.
Opting For Rejuran Treatment in Singapore
Rejuran is a scientifically backed, safe, and effective solution for skin healing and rejuvenation in Singapore. By harnessing the power of polynucleotides, it goes beyond surface hydration to repair the skin from within—restoring elasticity, smoothness, and long-term radiance.
At AEON Medical, treatments are led by Dr Jeslin Wong with a focus on personalised care, safety, and natural results. Are you ready to restore your skin’s youth and vitality? Book a consultation with AEON Medical today to start your Rejuran treatment.
Frequently Asked Questions
How long does it take to see results from Rejuran?
Most patients notice initial improvements in skin texture and hydration within 2–4 weeks after treatment. However, the full benefits—such as reduced wrinkles, firmer skin, and scar improvement—typically appear after a series of sessions and continue to build gradually over several months.
Is Rejuran suitable for sensitive skin?
Yes, Rejuran is suitable for sensitive skin because of its anti-inflammatory properties. It helps strengthen the skin barrier, calm redness, and restore balance.
How many sessions of Rejuran are needed?
A typical Rejuran treatment course involves 3–4 sessions spaced about 3–4 weeks apart. After completing the initial series, maintenance sessions every 6–12 months are recommended to preserve results.
What skin concerns can Rejuran help with?
Rejuran is effective for a wide range of skin concerns, including:
- Fine lines and wrinkles
- Acne scars and uneven texture
- Dull, tired-looking skin
- Loss of elasticity and firmness
- Weakened skin barrier or chronic sensitivity
Can Rejuran be combined with other treatments?
Yes. Many patients combine Rejuran with treatments such as lasers, hyaluronic acid skin boosters, or light-based therapies for enhanced results. However, combination plans should always be tailored to individual skin needs by a qualified doctor.
Is Rejuran a permanent solution?
Rejuran is not a permanent solution. Since the treatment works by stimulating the body’s natural healing and collagen production, results gradually fade as the skin continues to age. Maintenance Rejuran treatments are recommended for sustained benefits.